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Tissue specificity: Expressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056). According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithe
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide Catalytic activity: Quinine + NADPH + O(2) = 3-hydroxyquinine + NADP(+) + H(2)O Catalytic activity: Taurochenodeoxycholate + NADPH + O(2) = taurohyocholate + NADP(+) + H(2)O Catalytic activity: Lithocholate + NADPH + O(2) = hyodeoxycholate + NADP(+) + H(2)O Catalytic activity: Albendazole + NADPH + O(2) = albendazole S-oxide + NADP(+) + H(2)O Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide Catalytic activity: Quinine + NADPH + O(2) = 3-hydroxyquinine + NADP(+) + H(2)O Catalytic activity: Taurochenodeoxycholate + NADPH + O(2) = taurohyocholate + NADP(+) + H(2)O Catalytic activity: Lithocholate + NADPH + O(2) = hyodeoxycholate + NADP(+) + H(2)O Catalytic activity: Albendazole + NADPH + O(2) = albendazole S-oxide + NADP(+) + H(2)O Catalytic activity: 1,8-cineole + NADPH + O(2) = 2-exo-hydroxy-1,8-cineole + NADP(+) + H(2)O
Catalytic activity: Quinine + NADPH + O(2) = 3-hydroxyquinine + NADP(+) + H(2)O Taurochenodeoxycholate + NADPH + O(2) = taurohyocholate + NADP(+) + H(2)O Lithocholate + NADPH + O(2) = hyodeoxycholate + NADP(+) + H(2)O Albendazole + NADPH + O(2) = albendazole S-oxide + NADP(+) + H(2)O 1,8-cineole + NADPH + O(2) = 2-exo-hydroxy-1,8-cineole + NADP(+) + H(2)O
Similarity: Belongs to the cytochrome P450 family [IMAGE]
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