Gene content  |
| DCC ( by HUGO) |
| Deleted In Colorectal Carcinoma |
| Tumor suppressor gene |
| Deleted In Colorectal Carcinoma Colorectal Cancer Suppressor Immunoglobulin Superfamily DCC Subclass Member 1 Tumor Suppressor Protein DCC IGDCC1 MRMV1 DCC Subclass Immunoglobulin Superfamily Member 1 CRC18 CRCR1 Colorectal Tumor Suppressor Deleted In Colorectal Cancer Protein Immunoglobulin Superfamily DCC Subclass Member 1 Netrin Receptor DCC |
| NCBI: 18q21.3 Ensembl: 18q21.2 |
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| DCC_HUMAN | Size: 1447 amino acids | Mass: 158457 Da |
Tissue specificity: Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells [IMAGE] Pathway & Disease-focused R
Function: UniProtKB/Swiss-Prot Summary: DCC_HUMAN, P43146 Function: Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene
Similarity: Belongs to the immunoglobulin superfamily. DCC family Contains 6 fibronectin type-III domains Contains 4 Ig-like C2-type (immunoglobulin-like) domains [IMAGE]
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