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Subunit: Part of an E3 complex for neddylation composed of cullins, RBX1, UBE2M and CAND1. Interacts (via the C-terminus 50 AA) with CUL1, CUL2, CUL3, CUL4 and CUL5. Binds neddylated CUL1. Interacts (via the C-terminus 50 AA) directly with RBX1. Interacts preferentially with UBE2M-NEDD8 thioester (via N-terminus 1-26 AA) than with free UBE2M. Interacts with CAND1 when in complex with CUL1-RBX1 Sequence caution: Sequence=BAB15235.1; Type=Erroneous initiation; Note=Translation N-terminally extended; 2 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for DCUN1D1: 3TDU (3D) [IMAGE] 3TDZ (3D) [IMAGE]
Tissue specificity: Expressed in pancreas, kidney, placenta, brain and heart. Weakly or not expressed in liver, skeletal muscle and lung. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral ton
Function: UniProtKB/Swiss-Prot Summary: DCNL1_HUMAN, Q96GG9 Function: Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity) Gene Ontology (GO): 1 molecular function term: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding IPI 18826954 [IMAGE] Find genes that share ontologies with DCUN1D1 About GenesLikeMe Animal Models: [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DCUN1D1 [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DCUN1D1 [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DCUN1D1 [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DCUN1D1 miRNA Products: miRTarBase miRNAs that target DCUN1D1: hsa-mir-106b-5p (MIRT044328), hsa-mir-1 (MIRT023689) [IMAGE] Block miRNA regulation of human, mouse, rat DCUN1D1 using miScript Target Protectors [IMAGE] Selected qRT-PCR Assays for microRNAs that regulate DCUN1D1 (see all 44): hsa-miR-520e hsa-miR-302d hsa-let-7a-2* hsa-miR-624* hsa-miR-218 hsa-miR-3171 hsa-miR-372 hsa-miR-302b [IMAGE] SwitchGear 3'UTR luciferase reporter plasmid: DCUN1D1 3' UTR sequence Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for DCUN1D1 [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat DCUN1D1 Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for DCUN1D1 Clone Products: [IMAGE] OriGene clones in human, mouse for DCUN1D1 (see all 7) OriGene ORF clones in mouse, rat for DCUN1D1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector: DCUN1D1 (NM_020640) [IMAGE] Sino Biological Human cDNA Clone for DCUN1D1 [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCUN1D1 [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCUN1D1 Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for DCUN1D1 [IMAGE] Browse ESI BIO Cell Lines and PureStem Progenitors for DCUN1D1 [IMAGE] In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCUN1D1
Similarity: Contains 1 DCUN1 domain Contains 1 UBA-like domain [IMAGE]
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