Gene content
Symbol	DDR1 (-- by HUGO)
Name	discoidin domain receptor tyrosine kinase 1 (Previous names: discoidin domain receptor family, membe
Category	--
Alias	EC 2.7.10 discoidin domain receptor tyrosine kinase discoidin domain receptor member NEP DDR CAK MCK10 EDDR1 PTK3 NTRK4 epithelial discoidin domain-containing receptor PTK3A neuroepithelial tyrosine kinase RTK6 neurotrophic tyrosine type TRKE PTK3A protein tyrosine kinase 3A CD167 MCK-10 Cell adhesion kinase CD167a antigen Mammary carcinoma kinase 10 Discoidin receptor tyrosine kinase Protein-tyrosine kinase RTK-6 Epithelial discoidin domain receptor Tyrosine kinase DDR Protein-tyrosine kinase 3A Tyrosine-protein kinase CAK TRK HGK2 ENTRK4 CD167 antigen-like family member EC
Cytogenetic band	NCBI: 6p21.3    Ensembl: 6p21.33
Protein information	DDR1_HUMAN Size: 913 amino acids Mass: 101128 Da Subcellular location: Isoform 1: Membrane; Single-pass type I membrane protein Subcellular location: Isoform 2: Membrane; Single-pass type I membrane protein Subcellular location: Isoform 3: Secreted (Potential) Subcellular location: Isoform 4: Membrane; Single-pass type I mem Subunit: Interacts (via PPxY motif) with WWC1 (via WW domains) in a collagen-regulated manner. Forms a tripartite complex with WWC1 and PRKCZ, but predominantly in the absence of collagen Tissue specificity: Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the br Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily                        Contains 1 F5/8 type C domain                        Contains 1 protein kinase domain

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000421	Coagulation_fac_5/8-C_type_dom	Coagulation factor 5/8 type, C-terminal	Domain
	IPR000719	Prot_kinase_cat_dom	Protein kinase	Domain
	IPR001245	Ser-Thr/Tyr_kinase	Tyrosine protein kinase	Domain
	IPR002011	Tyr_kinase_rcpt_2_CS	Receptor tyrosine kinase, class II	Family
	IPR011009	Kinase-like_dom	Protein kinase-like	Domain
Blocks	IPB000421	Coagulation factor 5/8 type C domain (FA58C)	Coagulation factor 5/8 type C domain (FA58C)
	IPB000421	Coagulation factor 5/8 type C domain (FA58C) IPB002011 Receptor tyrosine kinase IPB008266 Tyrosine protein kinase	Coagulation factor 5/8 type C domain (FA58C)

DDR1 cross reference
PubMed Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene