Gene content
Symbol	DDR2 (-- by HUGO)
Name	discoidin domain receptor tyrosine kinase 2 (Previous names: discoidin domain receptor family, membe
Category	--
Alias	EC 2.7.10.1 EC 2.7.10 discoidin domain receptor tyrosine kinase NTRKR3 MIG20a TKT cell migration-inducing protein 20 TYRO10 discoidin domain-containing receptor discoidin domain receptor member hydroxyaryl-protein kinase Discoidin domain receptor migration-inducing gene 16 protein Discoidin domain-containing receptor tyrosine kinase neurotrophic tyrosine kinase receptor related Neurotrophic tyrosine receptor-related tyrosylprotein kinase Receptor protein-tyrosine kinase TKT CD167b antigen Tyrosine-protein kinase TYRO10 CD167 antigen-like family member
Cytogenetic band	NCBI: 1q23.3    Ensembl: 1q23.3
Protein information	DDR2_HUMAN Size: 855 amino acids Mass: 96736 Da Subcellular location: Cell membrane; Single-pass type I membrane protein PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] : 2WUH (3D) [IMAGE] 2Z4F (3D) [IMAGE] Secondary accessions: Q7Z730 Explore the universe of human proteins at neXtProt for DDR2: NX_Q16832 Post-transla Subunit: Binds hydroxyproline-rich sequence motifs in fibrillar, glycosylated collagen, such as the GQOGVMGFO motif, where O stands for hydroxyproline. Interacts with SRC. Interacts (tyrosine phosphorylated) with SHC1 Tissue specificity: Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily                        Contains 1 F5/8 type C domain                        Contains 1 protein kinase domain

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000421	Coagulation_fac_5/8-C_type_dom	Coagulation factor 5/8 type, C-terminal	Domain
	IPR000719	Prot_kinase_cat_dom	Protein kinase	Domain
	IPR001245	Ser-Thr/Tyr_kinase	Tyrosine protein kinase	Domain
	IPR002011	Tyr_kinase_rcpt_2_CS	Receptor tyrosine kinase, class II	Family
	IPR011009	Kinase-like_dom	Protein kinase-like	Domain
Blocks	IPB000421	Coagulation factor 5/8 type C domain (FA58C)	Coagulation factor 5/8 type C domain (FA58C)
	IPB000421	Coagulation factor 5/8 type C domain (FA58C) IPB002011 Receptor tyrosine kinase IPB008266 Tyrosine protein kinase	Coagulation factor 5/8 type C domain (FA58C)

DDR2 cross reference
PubMed Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene