Gene content    
DEK ( by HUGO)
DEK Oncogene
Oncogene
DEK Oncogene
DEK Oncogene (DNA Binding)
D6S231E
Protein DEK
NCBI: 6p22.3    Ensembl: 6p22.3
DEK_HUMANSize: 375 amino acidsMass: 42674 Da

  • Subunit: Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA 2 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for DEK: 1Q1V (3D) [IMAGE] 2JX3 (3D) [IMAGE]
  • Tissue specificity: Ubiquitous. Expressed at relatively high levels [IMAGE] Custom PCR Arrays for DEK Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for DEK OriGene qSTAR qPCR primer pairs in human, mouse for DEK [IMAGE] Pre-validated RT2 qPCR Prim
  • Function:
    UniProtKB/Swiss-Prot Summary: DEK_HUMAN, P35659 Function: Involved in chromatin organization
  • Similarity:
    Contains 1 SAP domain [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR003034SAP_domDNA-binding SAPDomain
    IPR009057Homeodomain-likeHomeodomain-likeDomain

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process regulation of transcription from RNA polymerase II promoter TAS GOA 9050861
    signal transduction TAS GOA 9050861
    transcription from RNA polymerase II promoter TAS GOA 9050861
    viral genome replication TAS GOA 9050861
    Molecular Function histone binding IDA GOA 12140263

    Disorder & Mutation    
    Source Disease
    Genatlasmyelodysplastic syndrome,refractory anemia with excess of blasts in transformation (MDS/RAEBT),acute myeloid leukemia of poor prognosis (AML),with t(6;9)(p23;q34) translocation
    SWISS-PROTNote=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with NUP214/CAN. It results in the formation of a DEK-CAN fusion gene

    DEK cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene