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Subunit: Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration Sequence caution: Sequence=AAB81637.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB21814.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; 5 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for DLC1: 2DKY (3D) [IMAGE] 2GYT (3D) [IMAGE] 2KAP (3D) [IMAGE] 2LOZ (3D) [IMAGE] 3KUQ (3D) [IMAGE]
Tissue specificity: Highest level of expression in the spleen, with rather lower levels in prostate, testis, ovary, small intestine and colon, but none in the thymus [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including DLC1: Lung Cancer in human mouse rat Leuk
Function: UniProtKB/Swiss-Prot Summary: RHG07_HUMAN, Q96QB1 Function: Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality
Similarity: Contains 1 Rho-GAP domain Contains 1 SAM (sterile alpha motif) domain Contains 1 START domain [IMAGE]
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