Gene content
Symbol	DMP1 ( by HUGO)
Name	Dentin Matrix Acidic Phosphoprotein 1
Category	Tumor suppressor gene
Alias	Dentin Matrix Acidic Phosphoprotein 1 Dentin Matrix Protein 1 DMP-1 ARHP ARHR Dentin Matrix Acidic Phosphoprotein
Cytogenetic band	NCBI: 4q21    Ensembl: 4q22.1
Protein information	DMP1_HUMAN Size: 513 amino acids Mass: 55782 Da Subunit: Interacts with importin alpha Tissue specificity: Expressed in tooth particularly in odontoblast, ameloblast and cementoblast [IMAGE] Custom PCR Arrays for DMP1 Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for DMP1 OriGene qSTAR qPCR primer pairs in human, mouse for DMP1 [IMA Function: UniProtKB/Swiss-Prot Summary: DMP1_HUMAN, Q13316 Function: May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR009889	DMP1	Dentin matrix 1	Family

Gene Ontology
Type	Term	Evidence	Source	Pub
Molecular Function	calcium ion binding	TAS	GOA	8509401
	integrin binding	TAS	GOA	8509401

Disorder & Mutation
Source	Disease
SWISS-PROT	Hypophosphatemic rickets, autosomal recessive, 1 (ARHR1) [MIM:241520]: A hereditary form of hypophosphatemic rickets, a disorder of proximal renal tubule function that causes phosphate loss, hypophosphatemia and skeletal deformities, including rickets and osteomalacia unresponsive to vitamin D. Symptoms are bone pain, fractures and growth abnormalities. Note=The disease is caused by mutations affecting the gene represented in this entry

DMP1 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene