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Subunit: Monomer Sequence caution: Sequence=AAH16844.1; Type=Erroneous initiation; 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for DUSP22: 1WRM (3D) [IMAGE]
Tissue specificity: Ubiquitous. Highest expression seen in heart, placenta, lung, liver, kidney and pancreas [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including DUSP22: Protein Phosphatases in human mouse rat Primer Products: [IMAGE] OriGene qSTAR qPCR primer
Function: Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity) Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity)
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481 Gene Ontology (GO): 4 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0004725 protein tyrosine phosphatase activity IEA -- GO:0005515 protein binding -- -- GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA -- GO:0016791 phosphatase activity -- -- [IMAGE] Find genes that share ontologies with DUSP22 About GenesLikeMe Phenotypes: 4 GenomeRNAi human phenotypes for DUSP22: Increased Erk phosphorylation Increased apoptosis Increased cell death HMECs cel Synthetic lethal with Ras Animal Models: [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DUSP22 [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DUSP22 [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DUSP22 [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DUSP22 miRNA Products: miRTarBase miRNAs that target DUSP22: hsa-mir-26b-5p (MIRT030306), hsa-mir-335-5p (MIRT019217) [IMAGE] Block miRNA regulation of human, mouse, rat DUSP22 using miScript Target Protectors [IMAGE] 5 qRT-PCR Assays for microRNAs that regulate DUSP22: hsa-miR-182 hsa-miR-205* hsa-miR-938 hsa-miR-1271 hsa-miR-96 [IMAGE] SwitchGear 3'UTR luciferase reporter plasmid: DUSP22 3' UTR sequence Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for DUSP22 [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat DUSP22 Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for DUSP22 Clone Products: [IMAGE] OriGene clones in human, mouse for DUSP22 (see all 9) OriGene ORF clones in mouse, rat for DUSP22 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector: DUSP22 (NM_020185) [IMAGE] Browse Sino Biological Human cDNA Clones [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP22 [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP22 Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for DUSP22 [IMAGE] Browse ESI BIO Cell Lines and PureStem Progenitors for DUSP22 [IMAGE] In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP22
Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily Contains 1 tyrosine-protein phosphatase domain [IMAGE]
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