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Subunit: Interacts with HSF4
Tissue specificity: Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array includ
Function: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK) Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK)
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481 Gene Ontology (GO): Selected molecular function terms (see all 8): About this table GO ID Qualified GO term Evidence PubMed IDs GO:0001102 RNA polymerase II activating transcription factor binding IPI 16581800 GO:0002039 p53 binding IPI -- GO:0004647 phosphoserine phosphatase activity IMP 15796912 GO:0004721 phosphoprotein phosphatase activity IDA 19043453 GO:0004725 protein tyrosine phosphatase activity IMP 15796912 [IMAGE] Find genes that share ontologies with DUSP26 About GenesLikeMe Phenotypes: 2 GenomeRNAi human phenotypes for DUSP26: Decreased G3BP1 protein expres Decreased focal adhesion (FA) 1 MGI mutant phenotype (inferred from 1 allele[IMAGE]) (MGI details for Dusp26): integument [IMAGE] Find genes that share phenotypes with DUSP26 About GenesLikeMe Animal Models: [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DUSP26 [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DUSP26 [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DUSP26 [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DUSP26 miRNA Products: [IMAGE] Block miRNA regulation of human, mouse, rat DUSP26 using miScript Target Protectors [IMAGE] 3 qRT-PCR Assays for microRNAs that regulate DUSP26: hsa-miR-1914 hsa-miR-636 hsa-miR-3605-5p [IMAGE] SwitchGear 3'UTR luciferase reporter plasmid: DUSP26 3' UTR sequence Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for DUSP26 [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat DUSP26 Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for DUSP26 Clone Products: [IMAGE] OriGene clones in human, mouse for DUSP26 (see all 6) OriGene ORF clones in mouse, rat for DUSP26 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector: DUSP26 (NM_024025) [IMAGE] Sino Biological Human cDNA Clone for DUSP26 [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP26 [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP26 Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for DUSP26 [IMAGE] Browse ESI BIO Cell Lines and PureStem Progenitors for DUSP26 [IMAGE] In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP26
Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily Contains 1 tyrosine-protein phosphatase domain [IMAGE]
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