Gene content    
EGR1 ( by HUGO)
Early Growth Response 1
Tumor suppressor gene
Early Growth Response 1
Nerve Growth Factor-Induced Protein A
Transcription Factor ETR103
Zinc Finger Protein 225
Early Growth Response Protein 1
Transcription Factor Zif268
Zinc Finger Protein Krox-24
AT225
EGR-1
NGFI-A
ZNF225
G0S30
KROX-24
TIS8
ZIF-268
KROX24
NCBI: 5q31.1    Ensembl: 5q31.2
EGR1_HUMANSize: 543 amino acidsMass: 57507 Da

  • Function:
    UniProtKB/Swiss-Prot Summary: EGR1_HUMAN, P18146 Function: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation
  • Similarity:
    Belongs to the EGR C2H2-type zinc-finger protein family
                          
    Contains 3 C2H2-type zinc fingers [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR007087Znf_C2H2Zinc finger, C2H2-typeDomain
    BlocksIPB007086C2H2-type zinc finger signatureC2H2-type zinc finger signature

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process positive regulation of transcription from RNA polymerase II promoter IDA GOA 19057511
    positive regulation of transcription, DNA-templated IDA GOA 12560508
    regulation of protein sumoylation IDA GOA 19057511
    transcription from RNA polymerase II promoter IDA GOA 19057511
    Cellular Component cytoplasm IDA GOA 19057511
    Molecular Function DNA binding IDA GOA 12560508
    protein binding IPI GOA 14979875
    sequence-specific DNA binding IDA GOA 1662794
    sequence-specific DNA binding transcription factor activity IDA GOA 12560508
    transcription regulatory region sequence-specific DNA binding IDA GOA 18718911

    EGR1 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene