Gene content    
EIF1 ( by HUGO)
Eukaryotic Translation Initiation Factor 1
Tumor suppressor gene
Eukaryotic Translation Initiation Factor 1
Protein Translation Factor SUI1 Homolog
A121
SUI1
EIF-1
EIF1A
ISO1
sui1iso1
Sui1iso1
eIF1
EIF1AY
NCBI: 17q21.2    Ensembl: 17q21.2
EIF1_HUMANSize: 113 amino acidsMass: 12732 Da

  • Subunit: Interacts with RENT2
  • Function:
    UniProtKB/Swiss-Prot Summary: EIF1_HUMAN, P41567 Function: Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA Gene Ontology (GO): 3 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003743 translation initiation factor activity NAS 10347211 GO:0008135 translation factor activity, nucleic acid binding TAS 10347211 GO:0044822 poly(A) RNA binding IDA -- [IMAGE] Find genes that share ontologies with EIF1 About GenesLikeMe Animal Models: [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EIF1 [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EIF1 [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EIF1 [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EIF1 miRNA Products: miRTarBase miRNAs that target EIF1: hsa-mir-10a-5p (MIRT047677), hsa-mir-10b-5p (MIRT047434), hsa-mir-16-5p (MIRT031390), hsa-mir-193b-3p (MIRT041198), hsa-mir-30a-5p (MIRT028444), hsa-mir-186-5p (MIRT044979) [IMAGE] Block miRNA regulation of human, mouse, rat EIF1 using miScript Target Protectors [IMAGE] Selected qRT-PCR Assays for microRNAs that regulate EIF1 (see all 25): hsa-miR-623 hsa-miR-323-3p hsa-miR-4317 hsa-miR-100* hsa-miR-4328 hsa-miR-300 hsa-miR-522 hsa-miR-570 [IMAGE] SwitchGear 3'UTR luciferase reporter plasmid: EIF1 3' UTR sequence Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for EIF1 [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat EIF1 Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for EIF1 Clone Products: [IMAGE] OriGene clones in human, mouse for EIF1 (see all 6) OriGene ORF clones in mouse, rat for EIF1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector: EIF1 (NM_001412) [IMAGE] Sino Biological Human cDNA Clone for EIF1 [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF1 [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF1 Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for EIF1 [IMAGE] Browse ESI BIO Cell Lines and PureStem Progenitors for EIF1 [IMAGE] In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF1
  • Similarity:
    Belongs to the SUI1 family [IMAGE]
  • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001950TIF_SUI1Translation initiation factor SUI1Family
    IPR005874SUI1_eukEukaryotic translation initiation factor SUI1Family
    BlocksIPB001950Translation initiation factor SUI1Translation initiation factor SUI1

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process regulation of translational initiation TAS GOA 10347211
    response to stress NAS GOA 10347211
    Cellular Component cytoplasm TAS GOA 10347211
    Molecular Function translation factor activity, nucleic acid binding TAS GOA 10347211
    translation initiation factor activity NAS GOA 10347211

    EIF1 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene