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Tissue specificity: Expressed in ovarian and colorectal cancer cell lines (at protein level). Highly expressed in testis. Overexpressed in some cancer cells [IMAGE] Custom PCR Arrays for EIF5A2 Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for EIF
Function: UniProtKB/Swiss-Prot Summary: IF5A2_HUMAN, Q9GZV4 Function: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity) Gene Ontology (GO): 4 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003723 RNA binding -- -- GO:0003746 translation elongation factor activity IEA -- GO:0005515 protein binding IPI 14622290 GO:0043022 ribosome binding IEA -- [IMAGE] Find genes that share ontologies with EIF5A2 About GenesLikeMe Phenotypes: 1 GenomeRNAi human phenotype for EIF5A2: Synthetic lethal with Ras Animal Models: [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EIF5A2 [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EIF5A2 [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EIF5A2 [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EIF5A2 miRNA Products: miRTarBase miRNAs that target EIF5A2: hsa-mir-106b-5p (MIRT020474), hsa-mir-7-5p (MIRT025671), hsa-mir-25-3p (MIRT050216) [IMAGE] Block miRNA regulation of human, mouse, rat EIF5A2 using miScript Target Protectors [IMAGE] Selected qRT-PCR Assays for microRNAs that regulate EIF5A2 (see all 97): hsa-miR-549 hsa-miR-607 hsa-miR-106a hsa-miR-146a hsa-miR-15a hsa-miR-134 hsa-miR-30d hsa-miR-578 [IMAGE] Browse SwitchGear 3'UTR luciferase reporter plasmids Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for EIF5A2 [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat EIF5A2 Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for EIF5A2 Clone Products: [IMAGE] OriGene clones in human, mouse for EIF5A2 (see all 7) OriGene ORF clones in mouse, rat for EIF5A2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector: EIF5A2 (NM_020390) [IMAGE] Sino Biological Human cDNA Clone for EIF5A2 [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF5A2 [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF5A2 [IMAGE] Addgene plasmids for EIF5A2 [IMAGE] Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for EIF5A2 [IMAGE] Browse ESI BIO Cell Lines and PureStem Progenitors for EIF5A2 [IMAGE] In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF5A2
Similarity: Belongs to the eIF-5A family [IMAGE]
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