Gene content    
ELK1 ( by HUGO)
ELK1, Member Of ETS Oncogene Family
Oncogene
ELK1
Member Of ETS Oncogene Family
ETS Domain-Containing Protein Elk-1
ETS-Like Gene 1
Tyrosine Kinase (ELK1) Oncogene
NCBI: Xp11.2    Ensembl: Xp11.23
ELK1_HUMANSize: 428 amino acidsMass: 44888 Da

  • Subunit: Interacts in its sumoylated form with PIAS2/PIASX which enhances its transcriptional activator activity. Interacts with MAD2L2; the interaction is direct and promotes phosphorylation by the kinases MAPK8 and/or MAPK9 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for ELK1: 1DUX (3D) [IMAGE]
  • Tissue specificity: Lung and testis [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including ELK1 (see all 9): Oncogenes & Tumor Suppressor Genes in human mouse rat G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat Toll-Like Receptor Signaling
  • Function:
    UniProtKB/Swiss-Prot Summary: ELK1_HUMAN, P19419 Function: Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum response factor and the ETS and SRF motifs of the fos serum response element
  • Similarity:
    Belongs to the ETS family
                          
    Contains 1 ETS DNA-binding domain [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR000418Ets_domEtsDomain
    IPR011991WHTH_DNA-bd_domWinged helix repressor DNA-bindingDomain

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process positive regulation of transcription from RNA polymerase II promoter IDA GOA 12750007
    positive regulation of transcription, DNA-templated IDA GOA 15790681
    Cellular Component nucleus IC GOA 14970218
    Molecular Function protein binding IPI GOA 16291755
    RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA GOA 12750007
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA GOA 12750007
    sequence-specific DNA binding transcription factor activity IDA GOA 14970218

    ELK1 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene