Gene content    
ELL ( by HUGO)
Elongation Factor RNA Polymerase II
Oncogene
Elongation Factor RNA Polymerase II
C19orf17
Eleven-Nineteen Lysine-Rich Leukemia Protein
Chromosome 19 Open Reading Frame 17
Protein Phosphatase 1
Regulatory Subunit 68
ELL1
MEN
PPP1R68
ELL Gene (11-19 Lysine-Rich Leukemia Gene)
Protein Phosphatase 1
Regulatory Subunit 68
RNA Polymerase II Elongation Factor ELL
NCBI: 19p13.1    Ensembl: 19p13.11
ELL_HUMANSize: 621 amino acidsMass: 68265 Da

  • Tissue specificity: Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes [IMAGE] Custom PCR Arrays for ELL Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for ELL OriGene qSTAR qP
  • Function:
    UniProtKB/Swiss-Prot Summary: ELL_HUMAN, P55199 Function: Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation
  • Similarity:
    Belongs to the ELL/occludin family [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR010844Occludin_RNApol2_elong_fac_ELLOccludin and RNA polymerase II elongation factor ELLDomain
    BlocksIPB010844Occludin and RNA polymerase II elongation factor ELLOccludin and RNA polymerase II elongation factor ELL

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process negative regulation of phosphatase activity IDA GOA 19389623
    positive regulation of DNA-templated transcription, elongation TAS GOA 8596958
    Cellular Component nuclear speck IDA GOA 19389623
    Molecular Function phosphatase binding IDA GOA 19389623
    protein binding IPI GOA 19389623

    Disorder & Mutation    
    Source Disease
    SWISS-PROTNote=A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with KMT2A/MLL1. The result is a rogue activator protein

    ELL cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene