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Subunit: Homotrimer associated through a moderately stable interaction of the C-terminal globular C1q domains, allowing the nucleation of the triple helix and then a further quaternary assembly to higher-order polymers via intermolecular disulfide bonds. Interacts with EMILIN2 Miscellaneous: Its deposition precedes the appearance of elastin and is simultaneous with that of fibrillin 1 2 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for EMILIN1: 2KA3 (3D) [IMAGE] 2OII (3D) [IMAGE]
Tissue specificity: Distributed in tissues where resilience and elastic recoil are prominent. Highest levels in the adult small intestine, aorta, lung, uterus, and appendix and in the fetal spleen, kidney, lung, and heart; intermediate expression was detected in adult liver,
Function: UniProtKB/Swiss-Prot Summary: EMIL1_HUMAN, Q9Y6C2 Function: May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity Gene Ontology (GO): 3 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding IPI 11278945 GO:0030023 extracellular matrix constituent conferring elasticity IEA -- GO:0042802 identical protein binding IEA -- [IMAGE] Find genes that share ontologies with EMILIN1 About GenesLikeMe Phenotypes:
Similarity: Contains 1 C1q domain Contains 1 collagen-like domain Contains 1 EMI domain [IMAGE]
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