Gene content    
ENC1 ( by HUGO)
Ectodermal-Neural Cortex 1 (With BTB Domain)
Tumor suppressor gene
Ectodermal-Neural Cortex 1 (With BTB Domain)
NRPB
PIG10
Ectodermal-Neural Cortex 1 (With BTB-Like Domain)
Kelch-Like Family Member 37
Kelch-Like Protein 37
Nuclear Matrix Protein NRP/B
ENC-1
KLHL37
P53-Induced Gene 10 Protein
CCL28
KLHL35
TP53I10
Ectoderm-Neural Cortex Protein 1
Kelch-Like 35
Nuclear Restricted Protein
BTB Domain-Like (Brain)
Tumor Protein P53 Inducible Protein 10
NCBI: 5q13    Ensembl: 5q13.3
ENC1_HUMANSize: 589 amino acidsMass: 66130 Da

  • Subunit: Binds to RB1. Hypophosphorylated RB1 associates with ENC1 during neuronal differentiation, while hyperphosphorylated RB1 associates with ENC1 in undifferentiating cells. Part of a complex that contains CUL3, RBX1 and ENC1. Interacts indirectly with KEAP1 Developmental stage: Dramatically up-regulated upon neuronal differentiation
  • Tissue specificity: Detected in fetal brain tissue, moderate expression in fetal heart, lung and kidney. Highly expressed in adult brain, particularly high in the hippocampus and amygdala, and spinal chord. Detectable in adult pancreas. May be down-regulated in neuroblastoma
  • Function:
    UniProtKB/Swiss-Prot Summary: ENC1_HUMAN, O14682 Function: Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism
  • Similarity:
    Contains 1 BTB (POZ) domain
                          
    Contains 6 Kelch repeats [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR000210BTB/POZ-likeBTB/POZDomain
    IPR006652Kelch_1Kelch repeatRepeat
    IPR011705BACKBTB/Kelch-associatedDomain
    BlocksIPB000210BTB/POZ domainBTB/POZ domain
    IPB011705BTB/Kelch-associatedBTB/Kelch-associated

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process multicellular organismal development TAS GOA 9566959
    negative regulation of translation IDA GOA 19424503
    nervous system development TAS GOA 9566959
    proteasomal ubiquitin-independent protein catabolic process IDA GOA 19424503
    protein ubiquitination IDA GOA 15983046
    Cellular Component Cul3-RING ubiquitin ligase complex IDA GOA 15983046
    cytoplasm IDA GOA 19424503
    Molecular Function protein binding IPI GOA 19424503

    ENC1 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene