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Subunit: Interacts with SGIP1 (By similarity). Interacts with HGS; the interaction bridges the interaction of STAM or STAM2 with EPS15. Isoform 2 interacts with HGS and AP2A2. Part of a complex at least composed of EPS15, HGS, and either STAM1 or STAM2. Binds AP2A2. Interacts with AP2B1; clathrin competes with EPS15. Binds STON2 and EPN1. Interacts (via its SH3-binding sites) with CRK. Interacts with SH3BP4/TTP. Interacts with ERBB2. Interacts with FCHO1. Interacts with FCHO2. Interacts (via EH domains) with DAB2 Caution: Studies in clathrin-mediated endocytosis of ITGB1 and TFR used a siRNA mixture of EPS15 and EPS15L1, and a Dab2 mutant with impaired binding to EH domain-containing proteins EPS15 and ITSN1 suggesting a partially overlapping role of the EH domain-containing proteins (PubMed:22648170) 6 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for EPS15: 1C07 (3D) [IMAGE] 1EH2 (3D) [IMAGE] 1F8H (3D) [IMAGE] 1FF1 (3D) [IMAGE] 2IV9 (3D) [IMAGE] 2JXC (3D) [IMAGE]
Tissue specificity: Ubiquitously expressed [IMAGE] Custom PCR Arrays for EPS15 Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in human, mouse for EPS15 [IMAGE] Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EPS15 [IMAGE] QuantiTect SYBR Green Assays in hu
Function: UniProtKB/Swiss-Prot Summary: EPS15_HUMAN, P42566 Function: Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2
Similarity: Contains 2 EF-hand domains Contains 3 EH domains Contains 2 UIM (ubiquitin-interacting motif) repeats [IMAGE]
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