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Subunit: Interacts with ERBB2, BPAG1 and ITGB4. May favor the localization of ERBB2, by restricting its presence to the basolateral membrane of epithelial cells. Also found to interact with ARVCF and delta catenin. Interacts (via C-terminus) with DST Isoform 3 (via N-terminus) Sequence caution: Sequence=AAH50692.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA91538.1; Type=Erroneous initiation; Note=Translation N-terminally extended; 6 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for ERBB2IP: 1MFG (3D) [IMAGE] 1MFL (3D) [IMAGE] 1N7T (3D) [IMAGE] 2H3L (3D) [IMAGE] 2QBW (3D) [IMAGE] 3CH8 (3D) [IMAGE]
Tissue specificity: Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including ERBB2IP: Inflammatory Response & Autoimmunity 384HT in human mouse rat Primer Products
Function: UniProtKB/Swiss-Prot Summary: LAP2_HUMAN, Q96RT1 Function: Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state Gene Ontology (GO): 4 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0005176 ErbB-2 class receptor binding TAS 11375975 GO:0005178 integrin binding IPI 11375975 GO:0005200 structural constituent of cytoskeleton NAS 11375975 GO:0005515 protein binding IPI 11375975 [IMAGE] Find genes that share ontologies with ERBB2IP About GenesLikeMe Phenotypes: 1 GenomeRNAi human phenotype for ERBB2IP: Synthetic lethal with Ras
Similarity: Belongs to the LAP (LRR and PDZ) protein family Contains 17 LRR (leucine-rich) repeats Contains 1 PDZ (DHR) domain [IMAGE]
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