Gene content
Symbol	ERF ( by HUGO)
Name	Ets2 Repressor Factor
Category	Tumor suppressor gene
Alias	Ets2 Repressor Factor PE-2 CRS4 PE2 ETS Domain-Containing Transcription Factor ERF
Cytogenetic band	NCBI: 19q13    Ensembl: 19q13.2
Protein information	ERF_HUMAN Size: 548 amino acids Mass: 58703 Da Tissue specificity: Highest levels in testis, ovary, pancreas, and heart [IMAGE] Custom PCR Arrays for ERF Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for ERF OriGene qSTAR qPCR primer pairs in human, mouse for ERF [IMAGE] Pre-validated RT2 qPCR Function: UniProtKB/Swiss-Prot Summary: ERF_HUMAN, P50548 Function: Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity) Similarity: Belongs to the ETS family                        Contains 1 ETS DNA-binding domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000418	Ets_dom	Ets	Domain
	IPR011991	WHTH_DNA-bd_dom	Winged helix repressor DNA-binding	Domain

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	cell cycle	NAS	GOA	7588608
	negative regulation of transcription from RNA polymerase II promoter	IDA	GOA	7588608
Molecular Function	transcription corepressor activity	IDA	GOA	7588608

Disorder & Mutation
Source	Disease
SWISS-PROT	Craniosynostosis 4 (CRS4) [MIM:600775]: A primary abnormality of skull growth involving premature fusion of one or more cranial sutures. The growth velocity of the skull often cannot match that of the developing brain resulting in an abnormal head shape and, in some cases, increased intracranial pressure, which must be treated promptly to avoid permanent neurodevelopmental disability. Note=The disease is caused by mutations affecting the gene represented in this entry

ERF cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene