Gene content
Symbol	ERG ( by HUGO)
Name	V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog
Category	Oncogene
Alias	V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog V-Ets Avian Erythroblastosis Virus E26 Oncogene Related Transcriptional Regulator ERG (Transforming Protein ERG) V-Ets Erythroblastosis Virus E26 Oncogene Like TMPRSS2-ERG Prostate Cancer Specific erg-3 ets-related p55 TMPRSS2/ERG Fusion Transcriptional Regulator ERG V-Ets Erythroblastosis Virus E26 Oncogene Homolog Transforming Protein ERG
Cytogenetic band	NCBI: 21q22.3    Ensembl: 21q22.2
Protein information	ERG_HUMAN Size: 486 amino acids Mass: 54608 Da Subunit: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SETDB1 4 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for ERG: 1SXE (3D) [IMAGE] 4IRG (3D) [IMAGE] 4IRH (3D) [IMAGE] 4IRI (3D) [IMAGE] Function: UniProtKB/Swiss-Prot Summary: ERG_HUMAN, P11308 Function: Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure Similarity: Belongs to the ETS family                        Contains 1 ETS DNA-binding domain                        Contains 1 PNT (pointed) domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000418	Ets_dom	Ets	Domain
	IPR003118	Pointed_dom	Sterile alpha motif/pointed	Domain
	IPR011991	WHTH_DNA-bd_dom	Winged helix repressor DNA-binding	Domain

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	cell proliferation	TAS	GOA	3476934
	multicellular organismal development	TAS	GOA	8502479
	protein phosphorylation	TAS	GOA	8502479
	signal transduction	TAS	GOA	8502479
Cellular Component	ribonucleoprotein complex	IDA	GOA	17289661
Molecular Function	DNA binding	TAS	GOA	8502479
	signal transducer activity	TAS	GOA	8502479

Disorder & Mutation
Source	Disease
SWISS-PROT	Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ERG has been found in patients with Erwing sarcoma. Translocation t(21;22)(q22;q12) with EWSR1
SWISS-PROT	Note=Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with FUS. Translocation t(X;21)(q25-26;q22) with ELF4

ERG cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene