Gene content
Symbol	ESRRB (-- by HUGO)
Name	estrogen-related receptor beta ------------------------------ (Previous names: deafness, autosomal r
Category	--
Alias	Estrogen-Related Receptor Beta ERR Beta-2 ESRL2 ERRbeta NR3B2 Deafness, Autosomal Recessive 35 DFNB35 ERRbeta-2 ERR2 Estrogen-Related Nuclear Receptor Beta ERRb Nuclear Receptor ERRB2 Estrogen Receptor-Like 2 Orphan Nuclear Receptor Nuclear Receptor Subfamily 3 Group B Member 2 Steroid Hormone Receptor ERR2 ERR-Beta ERR
Cytogenetic band	NCBI: 14q24.3    Ensembl: 14q24.3
Protein information	ERR2_HUMAN Size: 508 amino acids Mass: 56208 Da Subcellular location: Nucleus (Potential) 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for ESRRB: 1LO1 (3D) [IMAGE] Secondary accessions: A2VDJ2 B6ZGU4 Q5F0P7 Q5F0P8 Q9HCB4 Alternative splicing: 3 isoforms: O95718-1 O95718-2 O95718-3 Explore the universe of human pr Subunit: Binds DNA as a monomer Similarity: Belongs to the nuclear hormone receptor family. NR3 subfamily                        Contains 1 nuclear receptor DNA-binding domain

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR001723	Str_hrmn_rcpt	Steroid hormone receptor	Family
	IPR008946	Nucl_hormone_rcpt_ligand-bd	Steroid nuclear receptor, ligand-binding	Domain
Blocks	IPB000003	Retinoic acid receptor signature	Retinoic acid receptor signature
	IPB001723	Steroid hormone receptor signature	Steroid hormone receptor signature

Disorder & Mutation
Source	Disease
SWISS-PROT	Defects in ESRRB are the cause of deafness autosomal recessive type 35 (DFNB35) [MIM:608565]. DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information

ESRRB cross reference
PubMed Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene