Gene content
Symbol	ETV1 ( by HUGO)
Name	Ets Variant 1
Category	Oncogene
Alias	Ets Variant 1 Ets Variant Gene 1 Ets-Related Protein 81 ER81 ETS Translocation Variant 1
Cytogenetic band	NCBI: 7p21.3    Ensembl: 7p21.2
Protein information	ETV1_HUMAN Size: 477 amino acids Mass: 55131 Da Tissue specificity: Very highly expressed in brain, highly expressed in testis, lung and heart, moderately in spleen, small intestine, pancreas and colon, weakly in liver, prostate and thymus, very weakly in skeletal muscle, kidney and ovary and not in placenta and periphera Function: UniProtKB/Swiss-Prot Summary: ETV1_HUMAN, P50549 Function: Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' Similarity: Belongs to the ETS family                        Contains 1 ETS DNA-binding domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000418	Ets_dom	Ets	Domain
	IPR006715	ETS_PEA3_N	PEA3-type ETS-domain transcription factor, N-terminal	Domain
	IPR011991	WHTH_DNA-bd_dom	Winged helix repressor DNA-binding	Domain
Blocks	IPB006715	PEA3-type ETS-domain transcription factor	PEA3-type ETS-domain transcription factor, N-terminal

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	positive regulation of transcription from RNA polymerase II promoter	IDA	GOA	12750007
	transcription from RNA polymerase II promoter	TAS	GOA	7700648
Molecular Function	RNA polymerase II core promoter proximal region sequence-specific DNA binding	IDA	GOA	12750007
	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IDA	GOA	12750007
	sequence-specific DNA binding transcription factor activity	TAS	GOA	7700648

Disorder & Mutation
Source	Disease
SWISS-PROT	Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ETV1 is found in patients with Erwing sarcoma. Translocation t(7;22)(p22;q12) with EWSR1

ETV1 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene