Gene content    
EXTL2 ( by HUGO)
Exostosin-Like Glycosyltransferase
Tumor suppressor gene
Exostosin-Like Glycosyltransferase 2
Exostoses (Multiple)-Like 2
Alpha-1
4-N-Acetylhexosaminyltransferase EXTL2
Alpha-GalNAcT EXTL2
Glucuronyl-Galactosyl-Proteoglycan 4-Alpha-N-Acetylglucosaminyltransferase
EXTR2
EXT-Related Protein 2
4-N-acteylhexosaminyltransferase
alpha-1
Exostosin-Like 2
Processed Exostosin-Like 2
EC 2.4.1.223
NCBI: 1p21    Ensembl: 1p21.2
EXTL2_HUMANSize: 330 amino acidsMass: 37466 Da

  • Tissue specificity: Ubiquitous [IMAGE] Custom PCR Arrays for EXTL2 Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for EXTL2 OriGene qSTAR qPCR primer pairs in human, mouse for EXTL2 [IMAGE] Pre-validated RT2 qPCR Primer Assay in human, mouse, rat E
  • Function:
    Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains
                          
    Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains
  • Catalytic activity:
    UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan
  • Similarity:
    Belongs to the glycosyltransferase 47 family [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR004263ExostosinExostosin-likeFamily

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process N-acetylglucosamine metabolic process IDA GOA 10318803
    UDP-N-acetylgalactosamine metabolic process IDA GOA 10318803
    Cellular Component endoplasmic reticulum IDA GOA 10639137
    Molecular Function alpha-1,4-N-acetylgalactosaminyltransferase activity IDA GOA 10318803
    glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity IDA GOA 10318803

    EXTL2 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene