Gene content
Symbol	FANCG ( by HUGO)
Name	Fanconi Anemia, Complementation Group G
Category	Tumor suppressor gene
Alias	Fanconi Anemia Complementation Group G XRCC9 DNA Repair Protein XRCC9 X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 9 9 Complementing Defective In Chinese Hamster X-Ray Repair FAG Fanconi Anemia Group G Protein X-Ray Repair Complementing Defective In Chinese Hamster 9 Protein FACG
Cytogenetic band	NCBI: 9p13    Ensembl: 9p13.3
Protein information	FANCG_HUMAN Size: 622 amino acids Mass: 68554 Da Tissue specificity: Highly expressed in testis and thymus. Found in lymphoblasts [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including FANCG: DNA Damage Signaling Pathway in human mouse rat Primer Products: [IMAGE] OriGene qPCR primer pairs and template standard Function: UniProtKB/Swiss-Prot Summary: FANCG_HUMAN, O15287 Function: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene Gene Ontology (GO): 3 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003684 damaged DNA binding TAS 9806548 GO:0004871 signal transducer activity -- -- GO:0005515 protein binding IPI 10627486 [IMAGE] Find genes that share ontologies with FANCG About GenesLikeMe Phenotypes: Similarity: Contains 4 TPR repeats [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR001440	TPR_1	TPR repeat	Repeat
	IPR011990	TPR-like_helical	Tetratricopeptide-like helical	Domain

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	cell cycle checkpoint	TAS	GOA	9256465
	mitochondrion organization	IMP	GOA	17060495
Cellular Component	mitochondrion	IDA	GOA	17060495
Molecular Function	damaged DNA binding	TAS	GOA	9806548
	protein binding	IPI	GOA	10627486

Disorder & Mutation
Source	Disease
Genatlas	Fanconi anemia,autosomal recessive,complementation group G,characterized by progressive bone marrow failure (pancytopenia),often associated with skeletal abnormalities and an increased cancer risk and with spontaneous chromosomal breakage exacerbated by exposure to DNA cross-linking agents
SWISS-PROT	Fanconi anemia complementation group G (FANCG) [MIM:614082]: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Note=The disease is caused by mutations affecting the gene represented in this entry

FANCG cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene