|
Subunit: Component of the SCF(FBXW7) complex consisting of CUL1, RBX1, SKP1 and FBXW7. Interacts with PSEN1, cyclin E, NOTCH1 NICD, NOTCH4 NICD and SKP1. Interacts with MYC (when phosphorylated). Isoform 1 interacts with USP28, leading to counteract ubiquitination of MYC. Isoform 4 interacts (via WD repeats) with SV40 large T antigen (via CPD region). Forms a trimeric complex with NOTCH1 and SGK1 Sequence caution: Sequence=BAA91986.1; Type=Erroneous initiation;
Tissue specificity: Isoform 1 is widely expressed. Isoform 4 is expressed in brain [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including FBXW7: Ubiquitin Ligases in human mouse rat Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in human, mouse for FBXW
Function: UniProtKB/Swiss-Prot Summary: FBXW7_HUMAN, Q969H0 Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 Gene Ontology (GO): 3 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003700 sequence-specific DNA binding transcription factor activity IEA -- GO:0005515 protein binding IPI 15070733 GO:0042802 identical protein binding IPI -- [IMAGE] Find genes that share ontologies with FBXW7 About GenesLikeMe Phenotypes: 3 GenomeRNAi human phenotypes for FBXW7: Increased cell death HMECs cel Synthetic lethal with Ras Synthetic lethal with c-Myc af Selected MGI mutant phenotypes (inferred from 9 alleles[IMAGE]) (MGI details for Fbxw7) (see all 16): cardiovascular system cellular craniofacial digestive/alimentary embryogenesis growth/size/body hematopoietic system homeostasis/metabolism immune system integument mortality/aging nervous system normal respiratory system tumorigenesis [IMAGE] Find genes that share phenotypes with FBXW7 About GenesLikeMe Animal Models: MGI mouse knock-outs for FBXW7: Fbxw7tm1Sje Fbxw7tm1Kin Fbxw7tm1.2Axbe Fbxw7tm1.1Kei [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXW7 [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FBXW7 [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXW7 [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FBXW7 miRNA Products: miRTarBase miRNAs that target FBXW7: hsa-mir-107 (MIRT004756), hsa-mir-128-3p (MIRT004757), hsa-mir-16-5p (MIRT032006), hsa-mir-590-3p (MIRT016198), hsa-mir-223-3p (MIRT006237), hsa-mir-103a-3p (MIRT027232), hsa-mir-101-3p (MIRT027385), hsa-mir-197-3p (MIRT003827), hsa-mir-27a-3p (MIRT006357) [IMAGE] Block miRNA regulation of human, mouse, rat FBXW7 using miScript Target Protectors [IMAGE] Selected qRT-PCR Assays for microRNAs that regulate FBXW7 (see all 114): hsa-miR-194* hsa-miR-549 hsa-miR-188-5p hsa-miR-15a hsa-miR-128 hsa-miR-219-5p hsa-miR-4325 hsa-miR-3613-3p [IMAGE] SwitchGear 3'UTR luciferase reporter plasmid: FBXW7 3' UTR sequence Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for FBXW7 [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat FBXW7 Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for FBXW7 Clone Products: [IMAGE] OriGene clones in human, mouse for FBXW7 (see all 18) OriGene ORF clones in mouse, rat for FBXW7 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector (see all 3): FBXW7 (NM_018315) [IMAGE] Sino Biological Human cDNA Clone for FBXW7 [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXW7 [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW7 [IMAGE] Addgene plasmids for FBXW7 [IMAGE] Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for FBXW7 [IMAGE] Browse ESI BIO Cell Lines and PureStem Progenitors for FBXW7 [IMAGE] In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW7
Similarity: Contains 1 F-box domain Contains 7 WD repeats [IMAGE]
|
