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Subunit: Homodimer. Interacts with FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for FGF20: 3F1R (3D) [IMAGE]
Tissue specificity: Predominantly expressed in the cerebellum [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including FGF20: WNT Signaling Targets in human mouse rat Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in human, mouse for FGF20 [IMAGE] Pre-val
Function: UniProtKB/Swiss-Prot Summary: FGF20_HUMAN, Q9NP95 Function: Neurotrophic factor that regulates central nervous development and function [IMAGE]Summary: [IMAGE] During embryonic development, FGF20 as signaling molecule is secreted from the following cells: Tooth: Primary Enamel Knot Cells (Enamel Knot) It affects the following cells: Head Mesenchyme: Dental Mesenchymal Cells (Branchial Arch 1) Gene Ontology (GO): 2 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0005104 fibroblast growth factor receptor binding IEA -- GO:0008083 growth factor activity IEA -- [IMAGE] Find genes that share ontologies with FGF20 About GenesLikeMe Phenotypes: 1 GenomeRNAi human phenotype for FGF20: Increased cell death HMECs cel
Similarity: Belongs to the heparin-binding growth factors family [IMAGE]
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