Gene content    
FGF5 ( by HUGO)
Fibroblast Growth Factor 5
Oncogene
Fibroblast Growth Factor 5
Heparin-Binding Growth Factor 5
HBGF-5
Smag-82
FGF-5
NCBI: 4q21    Ensembl: 4q21.21
FGF5_HUMANSize: 268 amino acidsMass: 29551 Da

  • Subunit: Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors Developmental stage: Can transform NIH 3T3 cells Sequence caution: Sequence=AAB60698.1; Type=Erroneous gene model prediction;
  • Tissue specificity: Expressed in neonatal brain [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including FGF5: Notch Signaling Targets in human mouse rat Growth Factors in human mouse rat Cell Lineage Identification in human mouse rat Embryonic Stem Cells in human
  • Function:
    UniProtKB/Swiss-Prot Summary: FGF5_HUMAN, P12034 Function: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity)
  • Similarity:
    Belongs to the heparin-binding growth factors family [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR002209Fibroblast_GF_famHeparin-binding growth factor/Fibroblast growth factorFamily
    IPR008996Cytokine_IL1-likeCytokine, IL-1 relatedFamily
    BlocksIPB002209Heparin binding growth factor family signatureHeparin binding growth factor family signature
    IPB002348IL1/HBGF family signatureIL1/HBGF family signature

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process cell proliferation TAS GOA 3211147
    cell-cell signaling TAS GOA 9786939
    fibroblast growth factor receptor signaling pathway IDA GOA 8386828
    fibroblast growth factor receptor signaling pathway IGI GOA 8663044
    nervous system development TAS GOA 9786939
    positive regulation of cell proliferation IDA GOA 3211147
    positive regulation of cell proliferation IGI GOA 8663044
    Cellular Component extracellular space TAS GOA 9786939
    Molecular Function fibroblast growth factor receptor binding IDA GOA 8386828

    FGF5 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene