Gene content    
FGF6 ( by HUGO)
Fibroblast Growth Factor 6
Oncogene
Fibroblast Growth Factor 6
Heparin Secretory-Transforming Protein 2
Heparin-Binding Growth Factor 6
FGF-6
HBGF-6
HST-2
HST2
HSTF-2
HSTF2
NCBI: 12p13    Ensembl: 12p13.32
FGF6_HUMANSize: 208 amino acidsMass: 22905 Da

  • Subunit: Interacts with FGFR1, FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors Sequence caution: Sequence=CAA40359.1; Type=Erroneous initiation; Sequence=CAA40360.1; Type=Erroneous initiation;
  • Tissue specificity: Leukemia cell lines with platelet/ megakaryocytic differentiation potential [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including FGF6: cAMP / Ca2+ Signaling PathwayFinder in human mouse rat Growth Factors in human mouse rat Angiogenesis in
  • Function:
    UniProtKB/Swiss-Prot Summary: FGF6_HUMAN, P10767 Function: Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration
  • Similarity:
    Belongs to the heparin-binding growth factors family [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR002209Fibroblast_GF_famHeparin-binding growth factor/Fibroblast growth factorFamily
    IPR008996Cytokine_IL1-likeCytokine, IL-1 relatedFamily
    BlocksIPB002209Heparin binding growth factor family signatureHeparin binding growth factor family signature
    IPB002348IL1/HBGF family signatureIL1/HBGF family signature

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process cell proliferation TAS GOA 2649847
    cell-cell signaling TAS GOA 2649847
    fibroblast growth factor receptor signaling pathway IGI GOA 8663044
    positive regulation of cell proliferation IGI GOA 8663044
    signal transduction TAS GOA 2649847

    FGF6 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene