Gene content    
FHL2 ( by HUGO)
Four And A Half LIM Domains
Other
Four And A Half LIM Domains 2
DRAL
Skeletal Muscle LIM-Protein 3
FHL-2
SLIM-3
SLIM3
LIM Domain Protein DRAL
AAG11
Aging-Associated Gene 11
Down-Regulated In Rhabdomyosarcoma LIM Protein
Four And A Half LIM Domains Protein 2
NCBI: 2q12.2    Ensembl: 2q12.2
FHL2_HUMANSize: 279 amino acidsMass: 32193 Da

  • Subunit: Interacts with ZNF638 and TTN/titin. Interacts with E4F1. Interacts with GRB7. Interacts with SIRT1 and FOXO1 4 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for FHL2: 1X4K (3D) [IMAGE] 1X4L (3D) [IMAGE] 2D8Z (3D) [IMAGE] 2MIU (3D) [IMAGE]
  • Tissue specificity: Expressed in skeletal muscle and heart [IMAGE] Custom PCR Arrays for FHL2 Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in human, mouse for FHL2 [IMAGE] Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FHL2 [IMAGE] QuantiTect SYBR Green
  • Function:
    UniProtKB/Swiss-Prot Summary: FHL2_HUMAN, Q14192 Function: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation
  • Similarity:
    Contains 4 LIM zinc-binding domains [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001781Znf_LIMLIM, zinc-bindingDomain

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process androgen receptor signaling pathway NAS GOA 15572661
    negative regulation of apoptotic process IDA GOA 15692560
    negative regulation of transcription from RNA polymerase II promoter IDA GOA 15692560
    positive regulation of transcription, DNA-templated NAS GOA 15572661
    response to hormone IMP GOA 17975004
    Molecular Function androgen receptor binding NAS GOA 15572661
    identical protein binding IPI GOA 10906324
    protein binding IPI GOA 14550570
    transcription coactivator activity NAS GOA 15572661
    transcription factor binding IPI GOA 15692560

    FHL2 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene