Gene content    
FOXO1A (approved by HUGO)
forkhead box O1A (rhabdomyosarcoma)
Tumor suppressor gene
FKH1
FKHR
FOXO1
NCBI: 13q14.1    Ensembl: 13q14.11
FOXO1_HUMANSize: 655 amino acidsMass: 69648 Da

  • Subcellular location: Shuttles between cytoplasm and nucleus Post-translational modifications:
  • Tissue specificity: Ubiquitous
  • Function:
    Probable transcription factor
  • Similarity:
    Contains 1 fork-head DNA-binding domain.

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001766TF_Fork_headFork head transcription factorDomain
    IPR011991Wing_hlx_DNA_bdWinged helix repressor DNA-bindingDomain

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process nucleus IEA GOA
    transcription factor activity IEA GOA
    transcription factor activity TAS GOA PubMed
    Molecular Function anti-apoptosis TAS GOA PubMed
    regulation of transcription from RNA polymerase II promoter TAS GOA PubMed
    regulation of transcription, DNA-dependent IEA GOA
    transcription IEA GOA

    Disorder & Mutation    
    Source Disease
    SWISS-PROTChromosomal aberrations involving FOXO1A are a cause of rhabdomyosarcoma 2 (RMS2) [MIM:268220]; also known as alveolar rhabdomyosarcoma. Translocation (2;13)(q35;q14) with PAX3; translocation t(1;13)(p36;q14) with PAX7. The resulting protein is a transcriptional activator

    FOXO1A cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene