Gene content
Symbol	FRAT1 ( by HUGO)
Name	Frequently Rearranged In Advanced T-Cell Lymphomas
Category	Oncogene & --
Alias	Frequently Rearranged In Advanced T-Cell Lymphomas Frequently Rearranged In Advanced T-Cell Lymphomas 1 FRAT-1 Proto-Oncogene FRAT1
Cytogenetic band	NCBI: 10q24.1    Ensembl: 10q24.1
Protein information	FRAT1_HUMAN Size: 279 amino acids Mass: 29093 Da Subunit: Binds DVL1. Binds GSK-3 and prevent GSK-3-dependent phosphorylation 5 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for FRAT1: 1GNG (3D) [IMAGE] 3ZRK (3D) [IMAGE] 3ZRL (3D) [IMAGE] 3ZRM (3D) [IMAGE] 4AFJ (3D) [IMAGE] Function: UniProtKB/Swiss-Prot Summary: FRAT1_HUMAN, Q92837 Function: Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis Phenotypes: 1 GenomeRNAi human phenotype for FRAT1: Synthetic lethal with cisplati Similarity: Belongs to the GSK-3-binding protein family [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR008014	GSK3-bd	Glycogen synthase kinase-3 binding protein	Family
Blocks	IPB008014	Glycogen synthase kinase-3 binding protein	Glycogen synthase kinase-3 binding protein

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	Wnt receptor signaling pathway	IEA	GOA

FRAT1 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene