Gene content    
FVT1 (approved by HUGO)
follicular lymphoma variant translocation 1
Other
EC 1.1.1.102
FVT-1
NCBI: 18q21.3    Ensembl: 18q21.33
FVT1_HUMANSize: 332 amino acidsMass: 36187 Da

  • Subcellular location: Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein
  • Tissue specificity: Expressed in all tissues examined. Highest expression in placenta. High expression in lung, kidney, stomach and small intestine, low expression in heart, spleen and skeletal muscle. Weakly expressed in normal hematopoietic tissues. Higher expression in so
  • Function:
    Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS)
  • Catalytic activity:
    Sphinganine + NADP(+) = 3-dehydrosphinganine + NADPH
  • Similarity:
    Belongs to the short-chain dehydrogenases/reductases (SDR) family.

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR002198ADH_shortShort-chain dehydrogenase/reductase SDRFamily
    IPR002347Adh_short_C2Glucose/ribitol dehydrogenaseFamily
    BlocksIPB002198Short-chain dehydrogenase/reductase SDRShort-chain dehydrogenase/reductase SDR
    IPB002347Glucose/ribitol dehydrogenase family signatureGlucose/ribitol dehydrogenase family signature

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process 3-dehydrosphinganine reductase activity IEA GOA
    integral to membrane IEA GOA
    membrane IEA GOA
    metabolism IEA GOA
    oxidoreductase activity IEA GOA
    Molecular Function endoplasmic reticulum IEA GOA
    extracellular space TAS GOA PubMed

    FVT1 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene