|
Subunit: Interacts with MAGI3 and DVL1 (By similarity)
Tissue specificity: High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including FZD7 (se
Function: UniProtKB/Swiss-Prot Summary: FZD7_HUMAN, O75084 Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues
Similarity: Belongs to the G-protein coupled receptor Fz/Smo family Contains 1 FZ (frizzled) domain [IMAGE]
|
