Gene content
Symbol	GLI1 ( by HUGO)
Name	GLI Family Zinc Finger 1
Category	Oncogene
Alias	GLI Family Zinc Finger 1 GLI Glioma-Associated Oncogene Homolog 1 (Zinc Finger Protein) Oncogene GLI Glioma-Associated Oncogene Family Zinc Finger 1 GLI-Kruppel Family Member GLI1 Glioma-Associated Oncogene 1 Zinc Finger Protein GLI1 Glioma-Associated Oncogene
Cytogenetic band	NCBI: 12q13.2-q13.3    Ensembl: 12q13.3
Protein information	GLI1_HUMAN Size: 1106 amino acids Mass: 117904 Da Subunit: Interacts with KIF7 (By similarity). Interacts with ZIC1; the interaction enhances transcription activation Tissue specificity: Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including GLI1 (see all 7): Osteogenesis in human mouse Function: UniProtKB/Swiss-Prot Summary: GLI1_HUMAN, P08151 Function: Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation Similarity: Belongs to the GLI C2H2-type zinc-finger protein family                        Contains 5 C2H2-type zinc fingers [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR007087	Znf_C2H2	Zinc finger, C2H2-type	Domain
Blocks	IPB007086	C2H2-type zinc finger signature	C2H2-type zinc finger signature

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	digestive tract morphogenesis	TAS	GOA	11001584
	epidermal cell differentiation	IDA	GOA	12165851
	negative regulation of canonical Wnt signaling pathway	IMP	GOA	17035233
	osteoblast differentiation	IDA	GOA	12165851
	positive regulation of cell proliferation	IMP	GOA	12165851
	positive regulation of DNA replication	IDA	GOA	12165851
	positive regulation of smoothened signaling pathway	IDA	GOA	17035233
	positive regulation of transcription from RNA polymerase II promoter	IDA	GOA	10693759
	positive regulation of transcription, DNA-templated	IDA	GOA	11238441
	regulation of smoothened signaling pathway	TAS	GOA	11238441
	smoothened signaling pathway	IDA	GOA	19878745
	smoothened signaling pathway	TAS	GOA	11001584
Cellular Component	cytoplasm	IDA	GOA	10504446
	cytosol	IDA	GOA	18559511
Molecular Function	DNA binding	IDA	GOA	9118802
	protein binding	IPI	GOA	10564661
	transcription regulatory region DNA binding	IDA	GOA	17035233

GLI1 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene