TAG for GNA12

Gene content

Symbol

GNA12 ( by HUGO)

Name

Guanine Nucleotide Binding Protein (G Protein) Alpha 12

Category

Oncogene

Alias

Guanine Nucleotide Binding Protein (G Protein) Alpha 12
G Alpha-12
G-Protein Subunit Alpha-12
NNX3
RMP
WUGSC:H_GS165O14.2
gep
Guanine Nucleotide-Binding Protein Subunit Alpha-12

Cytogenetic band

NCBI: 7p22.2 Ensembl: 7p22.2

Protein information

GNA12_HUMAN

Size: 381 amino acids

Mass: 44279 Da

Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with UBXD5. Interacts (when active) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane

Function:

UniProtKB/Swiss-Prot Summary: GNA12_HUMAN, Q03113 Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. May play a role in the control of cell migration through the TOR signaling cascade Gene Ontology (GO): Selected molecular function terms (see all 9): About this table GO ID Qualified GO term Evidence PubMed IDs GO:0001664 G-protein coupled receptor binding -- -- GO:0003924 GTPase activity IBA -- GO:0004871 signal transducer activity IBA -- GO:0005515 protein binding IPI 10026210 GO:0005525 GTP binding IEA -- [IMAGE] Find genes that share ontologies with GNA12 About GenesLikeMe Phenotypes: 3 GenomeRNAi human phenotypes for GNA12: Bright nuclei Decreased Salmonella enterica Synthetic lethal with c-Myc af

Similarity:

Belongs to the G-alpha family. G(12) subfamily [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000469	Gprotein_alpha_12	G-protein alpha subunit, group 12	Family
	IPR001019	Gprotein_alpha_su	Guanine nucleotide binding protein (G-protein), alpha subunit	Family
	IPR011025	GproteinA_insert	G protein alpha subunit, helical insertion	Domain
Blocks	IPB000469	G-protein alpha subunit group 12 signature	G-protein alpha subunit group 12 signature
Blocks	IPB001019	Alpha G-protein (transducin) signature	Alpha G-protein (transducin) signature

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	G-protein coupled receptor signaling pathway	TAS	GOA	8290554
Molecular Function	protein binding	IPI	GOA	10026210

GNA12 cross reference