TAG for GNA13

Gene content

Symbol

GNA13 ( by HUGO)

Name

Guanine Nucleotide Binding Protein (G Protein), Alpha 13

Category

Oncogene

Alias

Guanine Nucleotide Binding Protein (G Protein)
Alpha 13
G Alpha-13
G-Protein Subunit Alpha-13
G13
Guanine Nucleotide-Binding Protein Subunit Alpha-13

Cytogenetic band

NCBI: 17q24.3 Ensembl: 17q24.1

Protein information

GNA13_HUMAN

Size: 377 amino acids

Mass: 44050 Da

Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with UBXD5. Interacts with HAX1. Interacts (when active) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane

Function:

UniProtKB/Swiss-Prot Summary: GNA13_HUMAN, Q14344 Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems Gene Ontology (GO): Selected molecular function terms (see all 10): About this table GO ID Qualified GO term Evidence PubMed IDs GO:0001664 G-protein coupled receptor binding -- -- GO:0003924 GTPase activity IBA -- GO:0004871 signal transducer activity IBA -- GO:0005515 protein binding IPI 10026210 GO:0005525 GTP binding IEA -- [IMAGE] Find genes that share ontologies with GNA13 About GenesLikeMe Phenotypes:

Similarity:

Belongs to the G-alpha family. G(12) subfamily [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000469	Gprotein_alpha_12	G-protein alpha subunit, group 12	Family
	IPR001019	Gprotein_alpha_su	Guanine nucleotide binding protein (G-protein), alpha subunit	Family
	IPR011025	GproteinA_insert	G protein alpha subunit, helical insertion	Domain
Blocks	IPB000469	G-protein alpha subunit group 12 signature	G-protein alpha subunit group 12 signature
Blocks	IPB001019	Alpha G-protein (transducin) signature	Alpha G-protein (transducin) signature

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	cellular component movement	TAS	GOA	8999798
Biological Process	signal transduction	TAS	GOA	7791744
Cellular Component	membrane	IDA	GOA	19946888
Molecular Function	protein binding	IPI	GOA	10026210

GNA13 cross reference