TAG for GNAI2

Gene content

Symbol

GNAI2 ( by HUGO)

Name

Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting...

Category

Other

Alias

Guanine Nucleotide Binding Protein (G Protein)
Alpha Inhibiting Activity Polypeptide 2
GNAI2B
GTP-Binding Regulatory Protein Gi Alpha-2 Chain
Adenylate Cyclase-Inhibiting G Alpha Protein
GIP
H_LUCA15.1
H_LUCA16.1
Guanine Nucleotide-Binding Protein G(I) Subunit Alpha-2
Guanine Nucleotide-Binding Protein G(I)
Alpha-2 Subunit

Cytogenetic band

NCBI: 3p21.31 Ensembl: 3p21.31

Protein information

GNAI2_HUMAN

Size: 355 amino acids

Mass: 40451 Da

Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with GPSM1. Interacts with RGS12 and RGS14 (By similarity). Interacts with UNC5B

Function:

UniProtKB/Swiss-Prot Summary: GNAI2_HUMAN, P04899 Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division Function: Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool

Similarity:

Belongs to the G-alpha family. G(i/o/t/z) subfamily [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR001019	Gprotein_alpha_su	Guanine nucleotide binding protein (G-protein), alpha subunit	Family
	IPR001408	Gprotein_alpha_I	G-protein alpha subunit, group I	Family
	IPR011025	GproteinA_insert	G protein alpha subunit, helical insertion	Domain
Blocks	IPB001019	Alpha G-protein (transducin) signature IPB001408 G-protein alpha subunit group I signature	Alpha G-protein (transducin) signature
Blocks	IPB001019	Alpha G-protein (transducin) signature	Alpha G-protein (transducin) signature

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	cell division	IMP	GOA	17635935
	G-protein coupled receptor signaling pathway	TAS	GOA	8587610
	negative regulation of adenylate cyclase activity	TAS	GOA	9637720
	response to nutrient	TAS	GOA	8587610
	signal transduction	TAS	GOA	7961880
Cellular Component	centrosome	IDA	GOA	17635935
	extracellular vesicular exosome	IDA	GOA	12519789
	membrane	IDA	GOA	19946888
	midbody	IDA	GOA	17635935
Molecular Function	protein binding	IPI	GOA	16189514

GNAI2 cross reference