TAG for GOLGA5

Gene content

Symbol

GOLGA5 ( by HUGO)

Name

Golgin A5

Category

Oncogene

Alias

Golgin A5
RFG5
Golgi Autoantigen
Golgin Subfamily A
5
Golgi Integral Membrane Protein 5
Cell Proliferation-Inducing Gene 31 Protein
RET-Fused Gene 5 Protein
GOLIM5
Golgin Subfamily A Member 5
golgin-84
ret-II
Golgin-84
RETII
Protein Ret-II
PTC5

Cytogenetic band

NCBI: 14q32.12 Ensembl: 14q32.12

Protein information

GOGA5_HUMAN

Size: 731 amino acids

Mass: 83024 Da

Subunit: Homodimer. Interacts with RAB1A that has been activated by GTP-binding, and possibly also with OCRL1. Interacts with isoform CASP of CUX1 Sequence caution: Sequence=CAA33787.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. A chimeric cDNA originating from chromosomes 14 and 10;

Tissue specificity: Ubiquitous. Highly expressed in seminiferous tubules and Leydig cells in testis, and detected at much lower levels in the other tissues tested. Expression is very low or not detectable in spermatozoa [IMAGE] Custom PCR Arrays for GOLGA5 Primer Products: [

Function:

UniProtKB/Swiss-Prot Summary: GOGA5_HUMAN, Q8TBA6 Function: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	Golgi organization	IMP	GOA	12538640
Biological Process	Golgi vesicle transport	IMP	GOA	12538640
Cellular Component	cis-Golgi network	IDA	GOA	12538640
	Golgi cisterna	IDA	GOA	12538640
	integral component of membrane	IDA	GOA	9915833
	membrane	IDA	GOA	19946888
Molecular Function	protein homodimerization activity	IPI	GOA	9915833
Molecular Function	Rab GTPase binding	IDA	GOA	12538640

Disorder & Mutation
Source	Disease
SWISS-PROT	Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving GOLGA5 is found in thyroid papillary carcinomas. Translocation t(10;14)(q11;q32) with RET. The translocation generates the RET/GOLGA5 (PTC5) oncogene which was found in 2 cases of PACT in children exposed to radioactive fallout after Chernobyl

GOLGA5 cross reference