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Subunit: Homotetramer 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for GPX2: 2HE3 (3D) [IMAGE]
Tissue specificity: Mostly in liver and gastrointestinal tract, not found in heart or kidney [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including GPX2 (see all 6): Nephrotoxicity in human mouse rat Oxidative Stress in human mouse rat Nitric Oxide Signaling Pat
Function: Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors
Catalytic activity: 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O
Similarity: Belongs to the glutathione peroxidase family [IMAGE]
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