Gene content    
GPX3 ( by HUGO)
Glutathione Peroxidase 3 (Plasma)
Tumor suppressor gene
Glutathione Peroxidase 3 (Plasma)
Extracellular Glutathione Peroxidase
Plasma Glutathione Peroxidase
GPx-3
GPx-P
GSHPx-3
GSHPx-P
EC 1.11.1.9
Glutathione Peroxidase 3
GPXP
EC 1.11.1
NCBI: 5q23    Ensembl: 5q33.1
GPX3_HUMANSize: 226 amino acidsMass: 25552 Da

  • Subunit: Homotetramer 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for GPX3: 2R37 (3D) [IMAGE]
  • Tissue specificity: Secreted in plasma [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including GPX3: Oxidative Stress in human mouse rat Nitric Oxide Signaling Pathway in human mouse rat Prostate Cancer in human mouse rat Molecular Toxicology PathwayFinder 384HT
  • Function:
    Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione
                          
    Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione
  • Catalytic activity:
    2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O
  • Similarity:
    Belongs to the glutathione peroxidase family [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR000889Glutathione_peroxidaseGlutathione peroxidaseFamily
    IPR012336Thioredoxin-like_foldThioredoxin-like foldDomain
    BlocksIPB000889Glutathione peroxidaseGlutathione peroxidase

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process hydrogen peroxide catabolic process TAS GOA 2491950
    protein homotetramerization IDA GOA 3693360
    response to lipid hydroperoxide TAS GOA 2491950
    Cellular Component extracellular space IDA GOA 1897960
    extracellular vesicular exosome IDA GOA 19199708
    Molecular Function glutathione peroxidase activity IDA GOA 1897960
    selenium binding IDA GOA 2491950
    transcription factor binding TAS GOA 8056346

    GPX3 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene