Gene content
Symbol	GSTT1 ( by HUGO)
Name	Glutathione S-Transferase Theta 1
Category	Tumor suppressor gene
Alias	Glutathione S-Transferase Theta 1 Glutathione Transferase T1-1 GST Class-Theta-1 EC 2.5.1.18 Glutathione S-Transferase Theta-1
Cytogenetic band	NCBI: 22q11.23    Ensembl: 22q11.23
Protein information	GSTT1_HUMAN Size: 240 amino acids Mass: 27335 Da Subunit: Homodimer Tissue specificity: Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at low levels in Clara cells and ciliated cells at the alveolar/bronchiolar junction. Absent from epithelial cells of larger bronchioles [IMAGE] Pathway & Disease-focused RT2 Profi Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide                        Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide Catalytic activity: RX + glutathione = HX + R-S-glutathione Similarity: Belongs to the GST superfamily. Theta family                        Contains 1 GST C-terminal domain                        Contains 1 GST N-terminal domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR004045	Glutathione_S-Trfase_N	Glutathione S-transferase, N-terminal	Domain
	IPR004046	GST_C	Glutathione S-transferase, C-terminal	Domain
	IPR010987	Glutathione-S-Trfase_C-like	Glutathione S-transferase, C-terminal-like	Domain
	IPR012336	Thioredoxin-like_fold	Thioredoxin-like fold	Domain

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	oxidation-reduction process	IDA	GOA	9307035
Cellular Component	cytosol	IDA	GOA	8799324
Molecular Function	glutathione peroxidase activity	IDA	GOA	9307035

GSTT1 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene