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Subunit: Interacts with RARB (By similarity). Interacts with RAB1 (RAB1A, RAB1B or RAB1C), RAB4 (RAB4A or RAB4B) and RAB11 (RAB11A or RAB11B); in a GTP-dependent manner. Interacts with RAC1; in a GTP-dependent manner. Interacts with the 26S proteasomal complex through the 20S core proteasomal subunit Developmental stage: Expressed in fetal and pediatric kidney cells Sequence caution: Sequence=BAA92558.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAG57487.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG62066.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAH14462.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAH71890.1; Type=Erroneous gene model prediction; Sequence=CAH74024.1; Type=Erroneous gene model prediction; Sequence=CAI16815.1; Type=Erroneous gene model prediction;
Tissue specificity: Expressed in multiple tissues including heart, brain and kidney [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including HACE1: Ubiquitin Ligases in human mouse rat Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for HA
Function: UniProtKB/Swiss-Prot Summary: HACE1_HUMAN, Q8IYU2 Function: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB
Similarity: Contains 6 ANK repeats Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain [IMAGE]
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