TAG for HGF

Gene content

Symbol

HGF ( by HUGO)

Name

Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor)

Category

Oncogene

Alias

Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor)
DFNB39
Scatter Factor
Fibroblast-Derived Tumor Cytotoxic Factor
Lung Fibroblast-Derived Mitogen
HPTA
SF
Deafness
Autosomal Recessive 39
Hepatopoietin A
F-TCF
HGFB
Hepatocyte Growth Factor
hepatopoeitin-A
hepatopoietin-A
Hepatopoietin-A
EC 3.4.21
EC 3.4.21.7

Cytogenetic band

NCBI: 7q21.1 Ensembl: 7q21.11

Protein information

HGF_HUMAN

Size: 728 amino acids

Mass: 83134 Da

Subunit: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity Caution: Has lost two of the three essential catalytic residues and so probably has no enzymatic activity Selected PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for HGF (see all 15): 1BHT (3D) [IMAGE] 1GMN (3D) [IMAGE] 1GMO (3D) [IMAGE] 1GP9 (3D) [IMAGE] 1NK1 (3D) [IMAGE] 1SHY (3D) [IMAGE]

Function:

UniProtKB/Swiss-Prot Summary: HGF_HUMAN, P14210 Function: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization

Similarity:

Belongs to the peptidase S1 family. Plasminogen subfamily

Contains 4 kringle domains

Contains 1 PAN domain

Contains 1 peptidase S1 domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000001	Kringle	Kringle	Domain
	IPR001254	Peptidase_S1	Peptidase S1 and S6, chymotrypsin/Hap	Domain
	IPR001314	Peptidase_S1A	Peptidase S1A, chymotrypsin	Domain
	IPR003014	PAN-1_domain	N/apple PAN	Domain
	IPR003609	Pan_app	Apple-like	Domain
	IPR009003	Trypsin-like_Pept_dom	Peptidase, trypsin-like serine and cysteine proteases	Domain
Blocks	IPB000001	Kringle	Kringle
	IPB001254	Serine protease	Serine protease, trypsin family
	IPB001314	Chymotrypsin serine protease family (S1) signature	Chymotrypsin serine protease family (S1) signature
	IPB001314	Chymotrypsin serine protease family (S1) signature IPB003014 N/apple PAN IPB003609 Apple-like	Chymotrypsin serine protease family (S1) signature

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	epithelial to mesenchymal transition	TAS	GOA	14679171
	mitotic nuclear division	NAS	GOA	2531289
	NOT proteolysis	NAS	GOA	2531289
	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	IDA	GOA	14517989
Cellular Component	membrane	IDA	GOA	19946888
Molecular Function	growth factor activity	NAS	GOA	2531289
	NOT serine-type endopeptidase activity	NAS	GOA	2531289
	protein binding	IPI	GOA	12694198

HGF cross reference