Gene content    
HINT1 ( by HUGO)
Histidine Triad Nucleotide Binding Protein 1
Tumor suppressor gene
Histidine Triad Nucleotide Binding Protein 1
PRKCNH1
HINT
Adenosine 5'-Monophosphoramidase
Protein Kinase C Inhibitor 1
Protein Kinase C-Interacting Protein 1
PKCI-1
NMAN
Histidine Triad Nucleotide-Binding Protein
Histidine Triad Nucleotide-Binding Protein 1
EC 3.-.-.-
PKCI1
NCBI: 5q31.2    Ensembl: 5q23.3
HINT1_HUMANSize: 126 amino acidsMass: 13802 Da

  • Subunit: Homodimer. Interacts with CDK7. Interacts with RUVBL1 and RUVBL2 and is associated with the LEF1/TCF1-CTNNB1 complex and with a KAT5 histone acetyltransferase complex. Identified in a complex with MITF and CTNNB1. Interacts with CDC34 and RBX1, and is part of a SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex Caution: Was originally thought to be a protein kinase C inhibitor and to bind zinc in solution. Both seem to be incorrect Selected PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for HINT1 (see all 10): 1AV5 (3D) [IMAGE] 1KPA (3D) [IMAGE] 1KPB (3D) [IMAGE] 1KPC (3D) [IMAGE] 1KPE (3D) [IMAGE] 1KPF (3D) [IMAGE]
  • Tissue specificity: Widely expressed [IMAGE] Custom PCR Arrays for HINT1 Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for HINT1 OriGene qSTAR qPCR primer pairs in human, mouse for HINT1 [IMAGE] Pre-validated RT2 qPCR Primer Assay in human, mouse,
  • Function:
    UniProtKB/Swiss-Prot Summary: HINT1_HUMAN, P49773 Function: Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex Enzyme Number (IUBMB): EC 3.-.-.-1 Gene Ontology (GO): 4 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0000166 nucleotide binding IEA -- GO:0003824 catalytic activity -- -- GO:0005080 protein kinase C binding TAS 9770345 GO:0016787 hydrolase activity IDA 16835243 [IMAGE] Find genes that share ontologies with HINT1 About GenesLikeMe Phenotypes: 1 GenomeRNAi human phenotype for HINT1: Decreased POU5F1-GFP protein e
  • Similarity:
    Belongs to the HINT family
                          
    Contains 1 HIT domain [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001310Histidine_triad_HITHistidine triad (HIT) proteinFamily
    BlocksIPB001310Histidine triad (HIT) proteinHistidine triad (HIT) protein

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process purine ribonucleotide catabolic process IDA GOA 16835243
    regulation of transcription, DNA-templated IMP GOA 16835243
    signal transduction TAS GOA 8812426
    Cellular Component cytoskeleton TAS GOA 8812426
    extracellular vesicular exosome IDA GOA 19056867
    histone deacetylase complex IDA GOA 16835243
    Molecular Function hydrolase activity IDA GOA 16835243
    protein kinase C binding TAS GOA 9770345

    Disorder & Mutation    
    Source Disease
    SWISS-PROTNeuromyotonia and axonal neuropathy, autosomal recessive (NMAN) [MIM:137200]: An autosomal recessive neurologic disorder characterized by onset in the first or second decade of a peripheral axonal neuropathy predominantly affecting motor more than sensory nerves. The axonal neuropathy is reminiscent of Charcot-Marie-Tooth disease type 2 and distal hereditary motor neuropathy. Individuals with NMAN also have delayed muscle relaxation and action myotonia associated with neuromyotonic discharges on needle EMG resulting from hyperexcitability of the peripheral nerves. Note=The disease is caused by mutations affecting the gene represented in this entry

    HINT1 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene