TAG for HMGA2

Gene content

Symbol

HMGA2 ( by HUGO)

Name

High Mobility Group AT-Hook

Category

Oncogene

Alias

High Mobility Group AT-Hook 2
HMGIC
High-Mobility Group (Nonhistone Chromosomal) Protein Isoform I-C
High Mobility Group AT-Hook Protein 2
BABL
HMGI-C
LIPO
STQTL9
High Mobility Group Protein HMGI-C
High-Mobility Group Protein HMGI-C

Cytogenetic band

NCBI: 12q15 Ensembl: 12q14.3

Protein information

HMGA2_HUMAN

Size: 109 amino acids

Mass: 11832 Da

Subunit: Interacts with E4F1. Interacts with NEK2 (By similarity) Developmental stage: Expressed predominantly during embryogenesis

Function:

UniProtKB/Swiss-Prot Summary: HMGA2_HUMAN, P52926 Function: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes Gene Ontology (GO): Selected molecular function terms (see all 20): About this table GO ID Qualified GO term Evidence PubMed IDs GO:0000975 regulatory region DNA binding IDA 17426251 GO:0000988 contributes to protein binding transcription factor activity IDA 18832382 GO:0001047 core promoter binding IDA 14627817 GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 18832382 GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 14627817 [IMAGE] Find genes that share ontologies with HMGA2 About GenesLikeMe Phenotypes: 2 GenomeRNAi human phenotypes for HMGA2: Decreased viability Increased HPV18 LCR reporter a

Similarity:

Belongs to the HMGA family

Contains 3 A.T hook DNA-binding domains [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000116	HMGI/HMGY	High mobility group proteins HMG-I and HMG-Y	Family
InterPro	IPR000637	HMGI/Y_DNA-bd_CS	HMG-I and HMG-Y, DNA-binding	Domain
Blocks	IPB000116	High mobility group protein (HMGY) signature	High mobility group protein (HMGY) signature

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	base-excision repair	IDA	GOA	19465398
	chromatin organization	TAS	GOA	19551524
	chromosome breakage	IDA	GOA	19549901
	DNA catabolic process, endonucleolytic	IDA	GOA	19465398
	DNA damage response, detection of DNA damage	IDA	GOA	19465398
	epithelial to mesenchymal transition	IMP	GOA	18832382
	fat cell differentiation	IMP	GOA	17624332
	heterochromatin assembly	IDA	GOA	16901784
	mesenchymal cell differentiation	IMP	GOA	17624332
	mesodermal cell differentiation	IMP	GOA	17624332
	mesodermal-endodermal cell signaling	IMP	GOA	17624332
	mitotic G2 DNA damage checkpoint	IDA	GOA	16061642
	multicellular organismal development	TAS	GOA	7606786
	negative regulation by host of viral transcription	IDA	GOA	17005673
	negative regulation of apoptotic process	IDA	GOA	19465398
	negative regulation of DNA binding	IDA	GOA	14645522
	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IDA	GOA	17005673
	negative regulation of transcription from RNA polymerase II promoter	IDA	GOA	14627817
	negative regulation of transcription, DNA-templated	IMP	GOA	16901784
	negative regulation of transcription, DNA-templated	IDA	GOA	18832382
	positive regulation of apoptotic process	IDA	GOA	16061642
	positive regulation of cell cycle arrest	IDA	GOA	16061642
	positive regulation of cellular senescence	IMP	GOA	16901784
	positive regulation of gene expression	IDA	GOA	18832382
	positive regulation of transcription from RNA polymerase II promoter	IDA	GOA	14645522
	positive regulation of transcription, DNA-templated	IMP	GOA	17624332
	positive regulation of transcription, DNA-templated	IDA	GOA	15225648
	regulation of cell cycle process	IDA	GOA	14645522
	regulation of stem cell maintenance	TAS	GOA	19551524
	regulation of stem cell maintenance	IMP	GOA	17624332
	regulation of transcription, DNA-templated	IMP	GOA	7606786
	response to virus	IEP	GOA	17005673
	stem cell differentiation	IEP	GOA	17078040
Cellular Component	nucleus	IDA	GOA	16901784
	protein-DNA complex	IDA	GOA	19465398
	SMAD protein complex	IDA	GOA	18832382
Molecular Function	5'-deoxyribose-5-phosphate lyase activity	IDA	GOA	19465398
	AT DNA binding	IMP	GOA	18832382
	AT DNA binding	IDA	GOA	14627817
	C2H2 zinc finger domain binding	IMP	GOA	14645522
	cAMP response element binding	IDA	GOA	14645522
	contributes_to transcription factor binding transcription factor activity	IDA	GOA	18832382
	core promoter binding	IDA	GOA	14627817
	DNA binding	NAS	GOA	8198613
	DNA binding, bending	IMP	GOA	14627817
	DNA-(apurinic or apyrimidinic site) lyase activity	IDA	GOA	19465398
	DNA-dependent protein kinase activity	IDA	GOA	19549901
	MH1 domain binding	IDA	GOA	18832382
	MH2 domain binding	IDA	GOA	18832382
	nucleosomal DNA binding	IDA	GOA	17078040
	protein binding	IPI	GOA	16293633
	regulatory region DNA binding	IDA	GOA	17426251
	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	IDA	GOA	14627817
	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IDA	GOA	18832382
	SMAD binding	IPI	GOA	18832382
	transcription factor binding	IPI	GOA	14645522

Disorder & Mutation
Source	Disease
SWISS-PROT	Note=A chromosomal aberration involving HMGA2 is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with LPP is shown in lipomas. HMGA2 is also fused with a number of other genes in lipomas
SWISS-PROT	Note=A chromosomal aberration involving HMGA2 is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with LPP is detected in pulmonary chondroid hamartomas
SWISS-PROT	Note=A chromosomal aberration involving HMGA2 is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with LPP is also shown in one parosteal lipoma

HMGA2 cross reference