Gene content    
HOXA9 ( by HUGO)
Homeobox A9
Other
Homeobox A9
HOX1G
HOX1
Homeobox Protein Hox-1G
Homeo Box A9
ABD-B
HOX1.7
Homeobox Protein Hox-A9
Homeodomain Protein HOXA9
NCBI: 7p15.2    Ensembl: 7p15.2
HXA9_HUMANSize: 272 amino acidsMass: 30172 Da

  • Subunit: Transiently interacts with PRMT5 in TNF-alpha stimulated endothelial cells Sequence caution: Sequence=AAC50364.1; Type=Erroneous initiation;
  • Function:
    UniProtKB/Swiss-Prot Summary: HXA9_HUMAN, P31269 Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation
  • Similarity:
    Belongs to the Abd-B homeobox family
                          
    Contains 1 homeobox DNA-binding domain [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001356Homeobox_domHomeoboxDomain
    IPR006711Hox9_activation_NHox9 activation regionDomain
    IPR009057Homeodomain-likeHomeodomain-likeDomain
    BlocksIPB000047Lambda and other repressor helix-turn-helix signatureLambda and other repressor helix-turn-helix signature
    IPB006711Hox9 activation regionHox9 activation region

    Gene Ontology    
    Type Term Evidence Source Pub
    Molecular Function protein binding IPI GOA 16189514

    Disorder & Mutation    
    Source Disease
    SWISS-PROTNote=A chromosomal aberration involving HOXA9 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with MSI2
    SWISS-PROTNote=A chromosomal aberration involving HOXA9 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with NUP98

    HOXA9 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene