Gene content    
HSD17B7 ( by HUGO)
Hydroxysteroid (17-Beta) Dehydrogenase 7
Tumor suppressor gene
Hydroxysteroid (17-Beta) Dehydrogenase 7
Estradiol 17-Beta-Dehydrogenase 7
17-Beta-HSD 7
17-Beta-Hydroxysteroid Dehydrogenase 7
Member 1
Short Chain Dehydrogenase/Reductase Family 37C
17 Beta-Hydroxysteroid Dehydrogenase Type VII
17beta Hydroxysteroid Dehydrogenase
3-Keto-Steroid Reductase
PRAP
SDR37C1
Short Chain Dehydrogenase/Reductase Family 37C
Member 1
EC 1.1.1.270
EC 1.1.1.62
NCBI: 1q23    Ensembl: 1q23.3
DHB7_HUMANSize: 341 amino acidsMass: 38206 Da

  • Tissue specificity: Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues tested. Isoform 3 is e
  • Function:
    Responsible for the reduction of the keto group on the C-3 of sterols Catalytic activity: A 3-beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + NADPH
                          
    Responsible for the reduction of the keto group on the C-3 of sterols
  • Catalytic activity:
    A 3-beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + NADPH
                          
    17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H
  • Similarity:
    Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR002198DH_sc/Rdtase_SDRShort-chain dehydrogenase/reductase SDRFamily
    IPR002347Glc/ribitol_DHGlucose/ribitol dehydrogenaseFamily
    BlocksIPB002198Short-chain dehydrogenase/reductase SDRShort-chain dehydrogenase/reductase SDR
    IPB002347Glucose/ribitol dehydrogenase family signatureGlucose/ribitol dehydrogenase family signature

    HSD17B7 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene