Gene content  |
| IGF2R ( by HUGO) |
| Insulin-Like Growth Factor |
| Tumor suppressor gene |
| Insulin-Like Growth Factor 2 Receptor MPRI Cation-Independent Mannose-6 Phosphate Receptor Insulin-Like Growth Factor II Receptor 300 KDa Mannose 6-Phosphate Receptor CI-MPR M6P/IGF2R M6PR CI Man-6-P Receptor IGF-II Receptor M6P/IGF2 Receptor MPR 300 CD222 CIMPR M6P-R MPR1 Cation-Independent Mannose-6-Phosphate Receptor CD222 Antigen |
| NCBI: 6q26 Ensembl: 6q25.3 |
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Subunit: Binds HA-I and HA-II plasma membrane adapters (By similarity). Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3 Selected PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for IGF2R (see all 13): 1E6F (3D) [IMAGE] 1GP0 (3D) [IMAGE] 1GP3 (3D) [IMAGE] 1GQB (3D) [IMAGE] 1JPL (3D) [IMAGE] 1JWG (3D) [IMAGE]
Function: UniProtKB/Swiss-Prot Summary: MPRI_HUMAN, P11717 Function: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4
Similarity: Belongs to the MRL1/IGF2R family Contains 1 fibronectin type-II domain [IMAGE]
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