Gene content
Symbol	IGFBP7 ( by HUGO)
Name	Insulin-Like Growth Factor Binding Protein 7
Category	Tumor suppressor gene
Alias	Insulin-Like Growth Factor Binding Protein 7 MAC25 Prostacyclin-Stimulating Factor Tumor-Derived Adhesion Factor IBP-7 IGFBP-7 IGFBP-rP1 PSF TAF IGF-Binding Protein 7 PGI2-Stimulating Factor RAMSVPS AGM FSTL2 IGFBP-7v IGFBPRP1 angiomodulin Insulin-Like Growth Factor-Binding Protein 7 MAC25 Protein
Cytogenetic band	NCBI: 4q12    Ensembl: 4q12
Protein information	IBP7_HUMAN Size: 282 amino acids Mass: 29130 Da Subunit: May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear Rna editing: Modified_positions=78, 95; Note=Partially edited. In the brain, position 78 is edited at about 55% and position 95 at about 31% Function: UniProtKB/Swiss-Prot Summary: IBP7_HUMAN, Q16270 Function: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain                        Contains 1 IGFBP N-terminal domain                        Contains 1 Kazal-like domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000867	IGFBP-like	Insulin-like growth factor-binding protein, IGFBP	Domain
	IPR002350	Kazal_dom	Proteinase inhibitor I1, Kazal	Family
	IPR003599	Ig_sub	Immunoglobulin subtype	Domain
	IPR007110	Ig-like_dom	Immunoglobulin-like	Domain
	IPR009030	Growth_fac_rcpt_N_dom	Growth factor, receptor	Domain
	IPR011390	IGFBP_rP_mac25	Insulin-like growth factor binding protein related protein (IGFBP-rP), MAC25	Family
	IPR013098	Ig_I-set	Immunoglobulin I-set	Domain
Blocks	IPB003599	Immunoglobulin subtype	Immunoglobulin subtype
	IPB011497	Protease inhibitor	Protease inhibitor, Kazal-type

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	cell adhesion	IDA	GOA	8117260
	negative regulation of cell proliferation	TAS	GOA	8939990
Molecular Function	protein binding	IPI	GOA	9388210

Disorder & Mutation
Source	Disease
SWISS-PROT	Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS) [MIM:614224]: An autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction. Note=The disease is caused by mutations affecting the gene represented in this entry

IGFBP7 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene